Abbreviation
Abbreviation (Also Known As)
CKD
Chronic Kidney Disease/ related to obesity/postulation of /insulin resistance to CVS risk factors. see below
A vision/dream/picture of teaching the masses
Time for a print out
Initiator
Prod / Activ
Prod / Activ
Jnl / Vol / Pg
Author / Yr
Misc / Vol / Ed
central obesity/atm
tnf
life
J Clin Invest. /May; 95(5): 2409–2415.
G S Hotamisligil, P Arner, J F Caro, R L Atkinson, and B M Spiegelman/1995
J Clin Invest. 1995 May; 95(5): 2409–2415.
M1 /macrophage of obesity
insulin resistance/
IL10
Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
Abbreviation
Abbreviation Known As
L atm
lean atm/ATMs /lean mice/ expressed many genes characteristic / M2 or alternatively activated/macrophages, including Ym1, arginase 1, and Il10/ Diet-induced obesity decreased expression of these genes in obese /ATMs
o atm
obese adipose macrophages
ATMs
Adipose tissue macrophages/involved insulin resistance /novel F4/80+CD11c/obese
o atm
obese adipose macrophages/ATMs from lean mice expressed many genes characteristic of M2 or "alternatively activated" macrophages, including Ym1, arginase 1, and Il10. Diet-induced obesity decreased expression of these genes in ATMs
ATMs
Adipose tissue macrophages/involved insulin resistance
Metabolic Syndrome and Kidney DiseaseEberhard RitzRuperto Carola University Heidelberg, Heidelberg, Germany
Blood Purification 2008;26:59-62
The clustering of cardiovascular risk factors was noted already a century ago, but it is only recently that a link between the CV risk cluster and insulin resistance has been postulated - a proposal which is not unanimously accepted. There is no doubt, however, that obesity per se impacts on renal function and the risk of chronic kidney disease (CKD). Particularly obesity early in life is an important predictor of CKD in adult life, but in adults as well a high body mass index (BMI) is an independent predictor of ESRD. The BMI threshold is lower in Asians. The link between obesity and CKD is not fully explained by the association between obesity and diabetes or hypertension respectively. Obesity is associated with increased glomerular filtration rate and renal blood flow, glomerulomegaly and in extreme cases focal segmental glomerulosclerosis. The causal role of obesity is underlined by the effect of weight loss on proteinuria and glomerular hyperfiltration. An even better predictor than BMI is visceral obesity (waist circumference). For kidney disease in the metabolic syndrome it is relevant that insulin resistance is linked to salt sensitivity and increased tubular reabsorption of sodium. Recent evidence points to adverse effects of aldosterone on podocytes, mediated by reactive oxygen species and resulting from hypothetical stimulants of aldosterone synthesis by visceral adipocytes.
Metabolic Syndrome and Kidney DiseaseEberhard RitzRuperto Carola University Heidelberg, Heidelberg, Germany
Blood Purification 2008;26:59-62
Initiator
Prod / Activ
Prod / Activ
Jnl / Vol / Pg
Author / Yr
Misc / Vol / Ed
M1 /macrophage of obesity
insulin resistance/
IL10
Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
obesity
Initiator
Prod / Activ
Prod / Activ
Jnl / Vol / Pg
Author / Yr
Misc / Vol / Ed
obesity BMI > 30, postmenopausal women/mod exercise
diminished signs of inflam
CRP/SAA
brain behav Imm/19/473
Ulrich, Cornelia/05
7th ISEI symposium abstracts
Obesity
sI-CAM-1/insulin resistance/metab syndrome ?
life
Metab /51/75
Straczkowski,M/02
METABOLIC SYNDROME :Note that only atherogenesis is missing AND I-CAM elevates this
M1 /macrophage of obesity
insulin resistance/
IL10
Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
central obesity/atm
tnf
life
J Clin Invest. /May; 95(5): 2409–2415.
G S Hotamisligil, P Arner, J F Caro, R L Atkinson, and B M Spiegelman/1995
J Clin Invest. 1995 May; 95(5): 2409–2415.
obesity
stroke/proinflammatory state
life
stroke
Carey N. Lumeng1,2, Jennifer L. Bodzin1 and Alan R. Saltiel1,3
Initiator
Prod / Activ
Prod / Activ
Jnl / Vol / Pg
Author / Yr
Misc / Vol / Ed
dm
Environmental factors/ obesity/tnf
wikepedia
dm
Environmental factors/ obesity
wikepedia
ART/Thymidine analogue
TO/Truncal Obesity
peripheral/extremities
HIV review
thaplial anna/swain, PK
Initiator
Prod / Activ
Prod / Activ
Jnl / Vol / Pg
Author / Yr
Misc / Vol / Ed
CRP
Bipolar/Manic Depresive/atherosclerosis/diminished PD pt erythropoiein response
life/obesity
amie
peters,a/07
Multiple stepwise linear regression analysis/revealed CRP to be of greater significance than nPCR/Albumin/PTH
Metabolic Syndrome and Kidney DiseaseEberhard RitzRuperto Carola University Heidelberg, Heidelberg, Germany
Blood Purification 2008;26:59-62
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